Phenylpiracetam (phenotropil) description
October 6th, 2008
FENOTROPIL (Phenotropil)
Description drug forms: tablets from white to white with a yellowish tinge or kremovatym color ploskotsilindricheskoy forms.
Pharmacological Effects: antiastenic, anticrampic.
Pharmacokinetics: rapidly absorbed, into the various organs and tissues readily passes through the GEB. The absolute oral bioavailability of 100 per cent. Cmax achieved in the blood after 1 hour, T1 / 2 hours at 3-5 No product in the body. Report the unchanged to: approximately 40% of the urine and 60% of export and then.
Pharmacodynamics: Has expressed antiamnesticheskim act has a direct impact on integrative activator of the brain contributes to the consolidation of memory, attention and concentration improves cognitive activity facilitates learning, enhances the speed of transmission of information between the brain hemispheres and sustainability of brain tissue to hypoxy and toxic effects, has anticrampic effect and anksiolitic activity, regulates processes activation and braking TSNS improves mood.
Has a positive impact on the exchange of blood and brain, stimulating redox processes, improves the body’s energy potential by utilization of glucose, regionarny improves blood flow in brain ishemizirovannyh stations. Increases noradrenalina, dofamina and serotonin in the brain, does not affect the level of background, not associated with GAMKA and GAMK B receptors, does not have significant effect on spontaneous activity Bioelectrical brain.
No effect on respiration and the cardiovascular system.
Enabling effect is the ability to Moderate effect by on motor reactions in improving physical performance, in katalepticheskomu expressed antagonism to the brain, as well as to lessen the pain vyrazhennosti of ethanol and geksobarbitala.
Moderate psihostimuliruyuschy effect of the drug combined with anksioliticheskoy activity, it improves mood, analgeziruyuschy has some effect, raising the threshold of pain sensitivity.
Adaptogennoe effect is to increase the body’s resistance to stress in the face of undue mental and physical fatigue while, hypokinesia and immobilization, at low temperatures.
While rtaking the drug noted improvement in (evident in the increasing severity, brightness and fields of view).
Improves circulation lower limbs.
It stimulates the development of antibodies in response to the introduction of antigen (indicating immunostimuliruyuschie properties), but at the same time contributes to the development of immediate-type hypersensitivity or allergic inflammatory changes of skin reactions caused by the introduction of foreign proteins.
In exchange application is not developed drug dependence, tolerance, “lifting” syndrome.
Effects manifested in one dose, which is important in the application of the drug in extreme conditions.
There has teratogenic, mutagenic, carcinogenic and embriotoksichnymi properties. It has low toxicity, acute lethal dose of the experiment is 800 mg / kg.
Indications: Diseases TSNS different genesis, especially those related to disease and violations of exchange processes in the brain, intoxication (in particular, the state of post-traumatic events and chronic cerebrovascular insufficiency), accompanied by the deterioration of intellectual functions mnesticheskih, reducing motor activity.
Nervous condition manifested apathy, high istoschaemostyu, lower psychomotor activity, in violation of attention, memory deterioration.
Violations of the learning process.
Depression light and medium gravity.
Psycho syndromes seen intellectual mnesticheskimi violations and apatiko- abulicheskimi phenomena, as well as vyaloapaticheskie state with schizophrenia.
Spasmodic condition.
Obesity (alimentary constitutional dysfunction).
Prevention hypoxy, increased resistance to stress, the functional correction of the body in extreme conditions of professional activity for the purpose of preventing the development of fatigue and to improve mental and physical performance, correction daily biorhythms, “Sung inversion cycle master.”
Chronic alcoholism (to reduce the phenomenon asthenia, depression, intellectual mnesticheskih violations).
Contraindications: Hypersensitivity.
Application of pregnancy and breast feeding: Do not appoint pregnancy and breast feeding because of the lack of clinical research.
Adverse actions: Insomnia (if I receive the drug later than 15 hours). Some patients in the first 1-3 days can receive psychomotor agitation, blood skin cover, feeling the heat, raising AD.
Networking: Fenotropil - may increase the effect of drugs that stimulate TSNS, antidepressants and other drugs nootropnyh.
Overdose: There was no overdose.
Treatment: symptomatic therapy.
Dosing and Administration: inside, immediately after the meal. Dose and duration of treatment should be determined by a physician. Doses vary depending on the characteristics of the patient. The average single dose of 150 mg (100 to 250 mg); Average daily dose of 250 mg (200 to 300 mg). The maximum permissible dose of 750 mg per day. Recommended daily dose of 100 mg taken once in the morning, and more than 100 mg of two separate admission. The duration of treatment may vary from 2 weeks to 3 months, on average, 30 days. If necessary, the course can be repeated after 1 month.
To improve efficiency, 100-200 mg once in the morning, during the two weeks (for athletes to 3 days).
The recommended length of treatment for patients with alimentary obesity is constitutional 30-60 days a dose of 100-200 mg once daily (in the morning).
Not to take Fenotropil - 15 hours later.
Precautions: Not recommended the appointment of children in the absence of data on drug use among children.
To use caution in patients with severe organic defeats liver and kidney during heavy hypertension, atherosclerosis in patients, in patients that had previously panic attacks, acute psihoticheskie status of ongoing with psychomotor stimulation, due to increased anxiety, panic, hallucinations and crazy, and patients, prone to allergic reactions to drugs nootropnye pirrolidona group.
When excessive psihoemotsionalnom depletion in the face of chronic stress and fatigue, chronic insomnia single admission Fenotropila - in the first day can cause sudden need for sleep. In patients in outpatients should be encouraged to start receiving the drug in exchange holidays.
Best before: 5 years
Storage conditions: in dry, sheltered from the world scene, at a temperature not exceeding 30 t C
Drug name: Lorano Quantity - 7
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Possible Side Effects: